- Prof. Jacob Vaya
- Animal Science - B.Sc. Program, Nutritional Sciences - B.Sc. Program
- [email protected]
- Organic Chemistry
- Oxidative stress and human diseases-atherosclerosis, Parkinson, Diabetic complications, stress,
- Non-covalent interactions of small molecules with proteins which alter proteins structute and functions
- Interelations between human carotid plaque and elements in the blood
The Oxidative Stress (OS) and Human Diseases group is focused on research related to the association between the two. This includes the design and use of multifunctional synthetic markers for the characterization of OS and application to human diseases. Markers are constructed from several subunits representing proteins, unsaturated fatty acids, sterols and DNA connected together covalently, and alterations in these markers due to OS are analyzed by LC/MS. These markers can be used ex vivo, by incubating them with body fluids (blood, urine, saliva), tissues (brain, plaques) or cells, or in vivo (by microdialysis technique, Vaya, Biochimie, 2012). 2). Early detection of human diseases, either associated with OS or not could be of highly important. Rationale: The biochemical pathways associated with human diseases such as degenerative neurological disorders are characterized by the generation of specific volatile organic compounds (VOCs) that can be detected in the blood using solid phase micro extraction (SPME) technique. Compounds formed due to specific metabolism linked to a particular disease may characterize the disease and be used as biomarkers of the disease presence and progression. (Khatib, et al., Neurochemistry International, 2014). 3.) Because human atherosclerotic plaques are in constant contact with blood, we are investigating the impact of the plaque components on blood elements and vice versa, to identify markers which may provide information on plaque vulnerability (Cohen et al., Journal of Lipids, 2012, FRBM 2014; Vaya et al., Current Opinion in Lipidology, 2013). 4.) In addition, the impact of interactions between small molecules and proteins on both is being investigated (Atrahimovich et al., Bioorganic & Medicinal Chemistry, 2013), and we are producing modified proteins (antibodies) with an immune-silencing response while preserving their native binding site (Gefen et al., Immunology, 2014).
Course: Organic Chemistry.
Course: Free Radicals and Oxidative Stress.
Course: Antibiotics- for graduate students (MSc).
Course: Oxido/redox homeostasis – for graduate students (MSc)